Study: Viagra, Cialis, Levitra Drugs May Promote Sexual Pleasure

August 30, 2007

According to a recent study, published at the Journal of Physiology, Sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) erectile dysfunction drugs may enhance sexual pleasure in addition to their well-known effect on sexual performance.

Viagra (sildenafil), Levitra (vardenafil), and Cialis (tadafil) treat erectile function by enhancing blood flow to the penis. They are classified as sexual stimulants, not aphrodisiacs, in that they improve sexual function but are not known to affect arousal.

However, the researchers indicated that these erectile dysfunction drugs play a key role (indirectly) in regulating release of oxytocin. This may be a key in understanding additional effects that these drugs may have on patient users.

Although the study was made on rats, results seem to show that sildenafil (Viagra) and its analogues seem to stimulate the release of oxytocin. This hormone is released by the neurohypophysis, or posterior pituitary, during orgasm.

Erectile dysfunction (ED or impotence) is a dysfunction characterized by the inability to develop or maintain an erection of the penis. Many underlying causes can be named for ED and many of those causes are medically treatable.

Many “treatments,” both medically approved and non-approved, have been suggested for ED. Since the 1930’s many folks have taken advantage of a highly devastating psychological sexual condition to push consumer to buy or try different treatments. Options on this are countless. However, the effectiveness of such so-called treatments for ED has not been proved.

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Controversial and unapproved treatments include naltrexone, bremelatonine, melanotan II, hMaxiK, Gingseng, Ezyte, herbal treatment, and Prelox.

Cyclic nucleotide phosphodiesterases are a group of chemical compounds that effectively have an effect on ED. One of the forms of phophodiesterase is termed PDE5. The prescription PDE5 inhibitors sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) are prescription drugs that are taken orally. They work by blocking the action of PDE5, allowing the penis to fill with blood.

The introduction of the first pharmacologically approved drug for ED, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, helped in part by heavy advertising.

The investigators wrote “Oxytocin also serves as a signal in central neuronal pathways associated with the erectile response”…. “If PDE5 inhibitors influence central oxytocin nerve terminals in the same way as peripheral nerve terminals of the posterior pituitary, then the activity of these central oxytocin pathways would be enhanced.”

The study suggests that Viagra (sildenafil), Levitra (vardenafil), and Cialis (tadafil) may have other effects (in addition to improve sexual performance), but the experiments were conducted only in animal systems. Further research is needed

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Yesterday’s trading: Buying tonic for gene-tech firm

August 23, 2007

Formerly known as SR Pharma, the London-based company is developing technology that can ’silence’ genes that cause disease. Last month, UK drugs giant AstraZeneca (26p better at 2404p) acquired a 2.94% stake after paying £5m to fund research in ST’s lead gene molecules, which are aimed at asthma and breathing diseases.

Sector analysts have often said in the past that the takeover of ST by a larger player in the drugs industry at some point is almost inevitable. Merck of the US forked out £500m for Sima Therapeutics last year, a rival to ST in the same field.

Cancer drug developer Antisoma jumped 4½p to 33p on hefty turnover of £6.2m. Buyers piled in on hearing an experimental cancer drug is being developing with Novartis of Switzerland that produced bullish final phase II results in patients suffering from non-small cell lung cancer.

Nomura Code said it was good news as it is the company’s lead product and a key value driver. The broker advised clients to buy and its fair value price is 51p.

Growing speculation that the Fed will soon cut interest rates by 50 basis points to ease fears of a credit crunch and sustain economic growth helped the Footsie march 109.9 points forward to 6,196. Many oversold second-line stocks found favour and the FTSE 250 soared 271.4 points to 10,910.7.

Wall Street rallied 129 points in the early stages with the overall mood helped by news of State-owned Dubai World’s £2.5bn purchase of a 9.5% stake in MGM Mirage, the number one entertainment group in Las Vegas which owns the super Mirage, Luxor and Bellagio hotels.

Rumours were rife too that TD Ameritrade and E.Trade were in merger talks which if successful would create a dominant player in the on-line brokerage industry.

Impressive full-year results from BHP Billiton (64p better at 1365p) and higher commodity prices put miners in the vanguard of the market’s advance. Lonmin rose 214p to 3177p, Rio Tinto 209p to 3280p, Antofagasta 40½p to 694½p, Kazakhmys 72p to 1250p, Anglo American 148p to 2752p and Xstrata 126p to 2881p. Credit information specialist Experian rose 33p to 525½p on rumouis of a pending bullish circular.

Drinks giant Punch Taverns rallied 62½p to 1039p after broker JP Morgan upgraded to overweight, believing the 28% fall in the stock over the past three months looks heavily overdone.

Whitbread bounced 68p higher to 1550p.

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Deutsche Bank advised clients to buy Reuters (12p dearer at 627p) and lifted its target price to 740p. The broker believes the combination of Thomson-Reuters creates the leading information solutions provider for professional markets. Synergies and legacy cost savings programmes should add over £500m to the starting EBITA base.

Industrial engineer Severfield-Rowen was top dog in the FTSE 250, climbing 184p to 2268p on acquisition news. It is buying Action Merchants, the holding company of Fisher Engineering, a steel fabricator, for £90m, of which £36.6m will be satisfied by the issue of 1.75m new shares at 2,089p.

Soon to replace Hanson in the Footsie, royal rat-catcher Rentokil rose 914p to 173p on turnover of 51.27m.

A Brewin Dolphin buy recommendation and target price of 240p in the wake of the AGM helped software and computer services group Touchstone rise 12p to 163p.

Shareholders were told that all of the delayed contracts alluded to at the prelims have now commenced.

None were lost to competitors or cancelled.

The company has also been confirmed as Microsoft’s top Dynamics partner in the UK for the third year running.

Impressive maiden interim results and net asset value of 230p a share lifted Delek Global Real Estate, the largest property company on AIM, 912p to 180p.

Sound Oil gushed 0.38p to 334p after reporting traces of oil and gas within the Baturaja Formation reservoir in Java, Indonesia.

Insurer Gable Holdings resumed trading and closed at 14½p. Trading is in line with expectations.

• The writing was on the wall in March when Interactive Prospect Target crashed 35% after a shock profits warning.

Predators have since kept a close eye on the e-mail marketing services and yesterday the shares jumped 27p to 13812p on confirmation that it is in ‘preliminary’ bid talks with certain parties.

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Man vs. Machine

August 18, 2007

t’s a sunshiny summer day–Californians just call it “weather”–but Jason Calacanis is air-conditioned cool in his new Santa Monica HQ. He’s hosting his weekly audio podcast, CalacanisCast, which gets upward of 30,000 listeners a week. Addressing call-in guest Brian Provost, a “search-engine optimizer” who gooses Google search results for a living, Calacanis recalls “a seminal blog post. I think it was ‘Jason Calacanis: Charlatan Douche Bag.’”

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Search Central Mahalo’s headquarters in Santa Monica, California, is currently home to 40 “guides” who build search results by hand.

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“My favorite,” says Provost.

“You also said you were going to knock me out at one point,” Calacanis adds.

“Nah, I said I was going to cut somebody a check if they knocked you out.”

Calacanis smirks. Barely 5-foot-9, the 36-year-old serial Web entrepreneur is a black belt in tae kwon do who grew up in the famously gritty Bay Ridge section of Brooklyn, where violence was as ubiquitous as graffiti. As a kid, he was tossed out of school for fighting and mopped blood off the floor of his father’s bar; his mother, an emergency-room nurse, would stitch up the combatants at a local hospital. It was a real family affair.

He introduces his next guest as the author of “Don’t Trust Jason Calacanis.” Then he welcomes a third search-engine optimizer, or SEO, Andy Beard, who dialed in from Poland. “You’ve written some great ones,” Calacanis tells him. “Like ‘How to Build a Biased Self-Propaganda Machine.’ A classic, classic post …”

It was, Beard says, “probably one of my most favorable posts for you.”

“One of your nicer ones,” Calacanis agrees.

It’s all so convivial, made more remarkable by the fact that they all can’t stand him. But you can’t blame Calacanis’s guests for wanting to stick it to him. He routinely blogs about his plan to put them out of business, calling SEOs “slime buckets” who are nothing more than “snake-oil salesmen” and “low-class idiots” who are “polluting” the Internet with “spam” sites. They are the ones responsible for “index spam,” which, at its worst, tries to trick search-engine Web crawlers so that a page about romantic holidays in Bordeaux ends up redirecting users to a site where they can purchase Viagra. For Calacanis, the junk they push is the equivalent of the penile-enhancement and penny-stock scams that clog your email inbox.

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To take these guys down, Calacanis is betting on his new online search engine, Mahalo (”thank you” in Hawaiian), which recently rolled out with $20 million in venture capital from a bevy of blue-chip investors–Sequoia Capital (original backer of Yahoo and Google); News Corp. (NYSE:NWS); CBS (NYSE:CBS); maverick Mark Cuban; and Elon Musk, the founder of PayPal, SpaceX, and now chairman of Tesla Motors, builder of the $100,000 iPod of electric cars. That high-tech breeding stock notwithstanding, Calacanis’s new venture is pure old school. He’s not unleashing some spicy new algorithm to power Mahalo. He’s using people. The company’s motto: “We’re here to help.”

Of course, hiring humans to do a machine’s work may seem more Web minus 1 than Web 2.0. But people know what other people want in a way a math equation can never intuit, like getting a living, breathing voice instead of an automated call system when you dial tech support. And for SEOs, it’s a lot harder to fool flesh and blood than to snow a machine.

At the end of the radio show, Calacanis wagers his “gray hat” guests they won’t be able to insert a “spammy link” in Mahalo.

No one will take him up on it.

And that’s the thing about Calacanis. Only a sucker would bet against him.

Not everyone hates Jason Calacanis, although for those who follow the latest skirmishes in the blogosphere, it may seem that way. The former publisher of Silicon Alley Reporter (it crashed and burned with the dotcoms) and the man behind Weblogs Inc., the blog syndicate he sold to AOL for a chill $25 million two years ago, welcomes any and all comers to the round-robin slugfest that is his online life. He posts his cell-phone number and email address on his blog, priming the flow of conflict. Not even his bosses are spared: While an executive at AOL, after the Weblogs purchase, Calacanis publicly advised his bloggers to quit if their new corporate parent tried to censor them–and bashed AOL’s own search engine, calling it “bad, very, very bad” from a user’s perspective. And he was right.

Calacanis’s archrival, Gawker Media tycoon Nick Denton, once described him as “brash,” “ballsy,” “publicity-hungry,” and “the Web’s answer to Donald Trump,” all in the same paragraph. Calacanis prefers to think of himself as honest, authentic–and there’s truth to that. He may dish it out, but he’s admirably thick-skinned, a necessity in the Hobbesian world of blogs, with its nasty, brutish, and short commentary. Calacanis is indeed transparent, but not only in the sense that his motives are clear (they are: He wants to get rich enough to buy the New York Knicks), but because he doesn’t hide what he thinks. As perennial pal Douglas Rushkoff, author of Get Back in the Box: Innovation From the Inside Out, puts it: “Jason would never stab you in the back. He might stab you in the face, though.”

The Calacanis saga has been rehashed so often it’s like a Web junkie’s version of E! True Hollywood Story. Calacanis is the working-class kid who started a grimy, 16-page, black-and-white newsletter, The Silicon Alley Reporter, that he’d stuff into newsstand racks when no one was looking. Early on, he realized there might be a healthy business in providing publicity for New York’s burgeoning tech community. And in a dazzling display of catch-22 logic, he knew if these Alley dotcomers became important, he would too–because he would be deciding who was important. His cynicism paid off nicely: Within five years, he was pulling in nearly $12 million in revenue.

With the money pouring in, Calacanis became a schmoozer nonpareil. He rented a loft, threw parties, organized conferences, and published a West Coast version of the magazine. Both Rushkoff and Calacanis held season tickets to Knicks games, Rushkoff sitting a dozen rows in front of his friend. But the ever-restless Calacanis never stayed in his seat long. “He’d start out the first quarter sitting behind me,” Rushkoff recalls, “but he’d invariably see someone he knew–a dotcomer, venture capitalist–and by the second quarter would end up sitting in front of me.”

By January 1999, as the market was about to peak, Calacanis and Rushkoff sat next to each other on a plane. Calacanis had just been offered $20 million for the Reporter and its associated conference business. But he was torn. Not yet 30, he was still a true believer.

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Market profile

August 15, 2007

Guy Fletcher is the founder of Aim-listed MCS, the biggest independent music publisher in Europe. He has written extensively for Tom Jones and Ray Charles, and was made an OBE for services to the music industry last year.

He was the first British composer to be recorded by Elvis Presley. His hit songs include Just Pretend and The Fair’s Movin On. Mr Fletcher talks about MCS’ troubles last year when Kingstreet Media went into administration owing it money and working with the Wombles.

What is the biggest threat to protecting copyright?

The internet is fast becoming a major platform for delivery of music in many different contexts. However, the advent of internet social networks, peer-to-peer file sharing, free downloading, etc. have created communication systems whose operators are generally unwilling to enter into licensing agreements with collection societies making it difficult, if not impossible for them to keep track of the online use of our copyrights. Much of the world’s music is therefore used for free.

How can composers protect copyright in the digital age?

Many wannabe Lily Allen’s think the fast route to fame is to upload their work on to MySpace, start a viral campaign and watch the money roll in. No matter how popular your song becomes, if you haven’t signed with a publisher like MCS, BMG or EMI who works within the collection societies network, you are unlikely to realise your dream. Writers and performers can, of course, do it all themselves but you need to be really savvy about licensing and copyright management to make it work.

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What was it like dealing with a company going into administration?

It was very stressful. We were owed a lot of money by a company that went into receivership and we felt somewhat powerless to do anything about it. Unfortunately, the British legal system seems to protect companies that owe the money.

Which performer have you most enjoyed working with?

Brownie McGee and Sonny Terry, when I was a teenage trumpet player and they were blues legends in their 80s.

Are you really on the lookout for a Chinese Cliff Richard?

I have written a number of songs for Cliff Richard including The Eurovision hit, Power to all our Friends, Sing a Song of Freedom, Baby You’re Dynamite, so that’s where the Chinese Cliff Richard stuff obviously comes from. It is true we have been on the lookout for an Asian “Cliff Richard” to appeal to the Asia-Pacific audience. Funnily enough, we have found one! A terrific young performer called Daniel Tse from Manchester.

What is your funniest moment as a songwriter?

Being arrested for trying to carry one of Mike Batt’s Womble suits through customs at Los Angeles airport. Mike Batt is one of the Britain’s best known songwriters and had eight hit singles and four gold albums with The Wombles.

What’s the oddest thing about being a quoted company?

With the impending take-private of EMI, we will be the only pure music publisher listed in London!

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The Family Redstone: multibillion history of dysfunction

August 7, 2007

HOLLYWOOD — In his twilight years, Sumner Redstone should be relaxed, fulfilled and enjoying the fruits of his labor.

From a hardscrabble upbringing in a working-class neighborhood in Boston, the 84-year-old Redstone has amassed a personal fortune of about $8 billion, making him one of America’s richest individuals.

The entertainment empire he built is among the world’s largest, with CBS, Paramount Pictures, Showtime, MTV, Comedy Central and Nickelodeon.

His wife of four years, Paula, is half his age and lives with him in a mansion with two swimming pools, a tennis court and screening room, in a posh gated community off Mulholland Drive.

Redstone’s collection of exotic fish can be viewed from his favorite chair in the den, where he compulsively watches the stock ticker on CNBC.

But instead of contentment, Redstone is entangled in a bitter public feud with his children and is estranged from practically every relative but his wife, according to people who know him well but spoke on condition of anonymity for fear of offending him.

Several of his relatives have sued him.

At the center of the dispute is National Amusements, the holding company founded by Redstone’s father as a theater circuit that today controls two publicly traded companies: CBS Corp. and Viacom.

One lawsuit threatens Redstone’s control of the media empire. Testimony and documents in that case, filed by Redstone’s nephew, provide an unprecedented glimpse into the lives of the extended family, including allegations of financial chicanery and betrayals worthy of a Charles Dickens novel.

The lawsuit claims Redstone cheated his two children and nephew out of portions of their inheritances to secure control over the family empire.

Over the years, Redstone has earned a reputation as a ruthless businessman, cunning legal strategist and limelight-seeking control freak.

A lawyer by training, he won Paramount and its parent company, Viacom, in bitter takeover battles. He is famous for suing his partners and pushing out chief executives who threaten his power or lack his fixation with the stock price.

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But his behavior in recent years has become erratic. Last summer, he publicly dismissed superstar Tom Cruise from Paramount without telling Viacom’s chief.

Days later, he fired Viacom CEO Tom Freston, who had built Redstone’s global cable juggernaut and was seen by many as his heir apparent.

Judgment questioned

Rivals say Redstone has lost his fastball. A split of his empire into two publicly traded companies in January 2006 has been deemed faulty by many on Wall Street.

Although CBS’ stock surged unexpectedly, Viacom’s has languished as consumers have turned to the Internet rather than to cable programming, leading to Freston’s ouster.

Redstone is showing signs of his age despite a passion for health shakes and antioxidants. Daily swims have replaced vigorous games of tennis. He shuffles feebly and no longer brags about taking Viagra.

That, perhaps, has brought the future of the family fortune into sharper relief for his relatives. Last year, his only son, Brent, 50, sued Redstone, accusing his father and sister, Shari, of freezing him out of the business.

His stake in National Amusements was bought out this year in a settlement.

Now, Shari, 53, anointed by her father a year ago as his heir apparent, is considering legal action.

She and her father have been at war for months over succession, corporate governance and the future of the theater chain she runs.

Shari is president of National Amusements and a vice chairwoman and director of CBS and Viacom. Her father is CEO of National Amusements and chairman of Viacom and CBS.

The father-daughter conflict recently became viciously public when Sumner, in a letter to Forbes magazine, disparaged Shari as having made “little or no contribution” to the entertainment empire he built.

Meanwhile, another family spat, playing out in a Massachusetts court, potentially could be more costly to Redstone, threatening the mogul’s control of National Amusements.

Nephew’s suit

Filed in November by Michael Redstone, Sumner’s nephew, and by the trustees of three trusts established decades ago by Sumner’s father, Mickey, the suit alleges Sumner wrested control of National Amusements by secretly engineering a purchase of shares from the family trusts at low-ball prices in 1972 and 1984.

The redemptions, Michael Redstone contends, cheated Sumner’s own children as well as his brother Edward’s children, and their heirs, of their rightful interests. Edward also is named as a defendant.

If Michael and his co-plaintiffs prevail, they would end up with a majority 54.5 percent ownership of National worth an estimated $4.36 billion, according to the complaint. Sumner would become a minority shareholder.

Edward Redstone could not be reached for comment for this story. Sumner’s spokesman Carl Folta said Redstone would not discuss pending litigation.

But Sumner previously has dismissed the case as “baseless.” His attorneys have contended the transactions were completely above board and approved by trustees.

They say the statutes of limitations have passed, although the plaintiffs contend the real nature of the transactions did not become known until recently, when pertinent financial documents were produced in two other lawsuits.

Massachusetts Superior Court Judge Allan vanGestel is pondering a motion from defense lawyers to throw the case out on grounds that the statute of limitations has passed. If he allows the case to proceed, a trial would begin in March, at the earliest.

At the moment, the dispute between Shari and her father seems likely to wind up in litigation, say people close to the matter. Some say Shari is questioning whether her father may have engaged in self-dealing and used National Amusements funds for his own benefit.

According to people close to the talks, one outcome could see Shari exchanging her rights to automatically succeed her father at National Amusements, Viacom and CBS upon his death for control of the theater chain she runs and its 1,000 screens.

She could leave the family business altogether. In a recent statement, she said she “would consider” a sale of her 20 percent stake in National at the current market value of about $1.6 billion.

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At the heart of the Redstone saga is the theater business founded in the 1930s by Mickey Redstone (born Max Rothstein), a former linoleum peddler, liquor wholesaler and nightclub operator.

In 1959, when the business reached down the Eastern seaboard, it was incorporated as National Amusements.

Mickey gave 200 of its 300 shares to Sumner and Edward with instructions that at least half were to be placed in a trust for their children. A decade later he placed his own shares in a trust for his four grandchildren.

Edward and Sumner were executives at National, but court documents suggest Edward believed he was frozen out by his father and brother.

He seems to have considered his father a domineering, even terrifying, figure: When his mother injected herself into a 1972 family blowup, he wrote her: “I don’t mean to be unkind, [but] you are the result of receiving years of unbelievable cruelty from Dad.”

That dispute arose from Edward’s decision to quit National. Court papers suggest his strained relationship with his father and Sumner was leading him to a physical and emotional breakdown.

When he learned Sumner had hired a new managing executive for National — supposedly behind his back — Edward exploded in a violent confrontation with his brother:

“You shoved me and said you would like to throw me out the window,” Sumner recounted in a nine-page, single-spaced letter written in 1971 detailing their deteriorating relationship.

But Edward was pushed to the brink, according to court documents.

“Under all the laws of God, there is no justification for Sumner’s and Dad’s activities,” he wrote his mother. “The immorality of their activities is almost beyond belief. … Historically, Dad and Sumner steamrolled over anyone they think they can.”

Mickey, taking Sumner’s side, wrote Edward back: “You obviously cannot cope with your problems. … You have tried professional help, and it obviously hasn’t helped.”

In 1972, National agreed to pay Edward $5 million for a 27 percent stake. That included his shares and those held in trust for his two children, Michael and Ruth Ann.

Michael contends in his suit that Edward kept the proceeds for himself.

That deal was only the prelude for what Michael and his co-plaintiffs contend was a greater fraud by Sumner: the 1984 repurchase of the grandchildren’s trust shares that had been put in place by Mickey.

By the early 1980s, Sumner had grown convinced that movie theaters were in deep trouble as cable TV encroached on their turf, and Home Box Office, the premier pay-TV channel, contemplated production. Theater attendance had stagnated.

Under Sumner’s guidance, National Amusements began to invest heavily in entertainment companies, including Viacom and Metro Goldwyn Mayer. Sumner also moved to solidify his control of National by buying up shares belonging to the next generation.

This was made easier because Sumner was a trustee of the grandchildren’s trusts and sole trustee of trusts he had created with shares from his father for his own children.

The role arguably placed him in a conflict of interest.

Court documents indicate he signed the 1984 transaction as buyer and seller — as president of National Amusements and as trustee for Mickey’s grandchildren.

The appraisal of the grandchildren’s stock was done in 1982 by Sam Rosen, Sumner’s personal accountant and the accountant for National.

Michael and his co-plaintiffs allege Rosen grossly undervalued the company and therefore the grandchildren’s holdings. The repurchase gave Sumner two-thirds of National’s shares, and the trusts for Brent and Shari, the rest.

Meanwhile, the trusts for Edward’s children and one for all four grandchildren — accounting for a 45 percent stake in the company — was bought out for $21.4 million, even though National’s real-estate alone was worth more than $150 million.

Now the undisputed owner of National, Sumner embarked on the investment spree that would transform the company into a worldwide entertainment power.

In 1987 he took over Viacom, and eventually added Paramount and CBS.

But none of this brought peace to the House of Redstone. Instead, there were more lawsuits, including one in 2004 that produced the financial documents Michael’s suit claims Sumner and Edward had kept secret from their children for more than 20 years.

And what’s left of the Redstone family? Mickey died in 1987 at age 85. Edward, who married his brother’s stockbroker, retired to Rancho Mirage, Calif.

His daughter, Ruth Ann, also died in 1987, after having dropped out of sight in the Far East. Her son Gabriel Adam died in 200 at 20 in a California motorcycle accident.

For his part, Michael, after being rescued from a mental hospital by Sumner, served as an executive at National Amusements before leaving recently and suing his uncle.

Brent, who has three children, followed in his father’s footsteps by becoming a lawyer. He and his wife, Annie, live on a sprawling ranch outside Denver.

Shari, divorced with two children, is the only Redstone besides Sumner in a top executive position within the family business.

That relationship appears to be headed down the same road to the courthouse as so many previous Redstone family disputes.

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Treating with Viagra!

August 2, 2007

Viagra, an oral drug for male impotence, may also help treat non-sexual problems like pulmonary hypertension and mountain sickness, says a new study.

Sildenafil, a drug manufactured under the trade name Viagra, has been in the market for the longest amount of time and is the most studied.

Viagra is now also marketed under the name Revatio for the treatment of pulmonary hypertension the uncommon but serious disorder of high pressure in the blood vessels leading to the lungs.

The condition leads to shortness of breath, dizziness, fainting and other symptoms.

The new report on the use of Viagra appeared in the August 2007 issue of Harvard Men’s Health Watch.

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Although it’s yet not clear if the other erectile dysfunction (ED) pills offer similar benefits, but Viagra may prove useful for some other conditions like mountain sickness, Raynaud’s phenomenon and heart disease.

Mountain sickness is an illness that ranges from a mild headache and weariness to a life-threatening build-up of fluid in the lungs or brain at high altitudes.

The report said Viagra could reduce pulmonary artery pressure at high altitude and improve the ability to exercise in low oxygen conditions.

Raynaud’s Phenomenon is a condition in which poor blood flow results in discomfort and skin colour changes in affected parts of the body.

If left untreated or uncontrolled, it can affect fingers, toes, ears, nose and knees. There is no cure for the disease but it can be controlled in most cases.

Both Viagra and Levitra, another ED medication, have been helpful in clinical trials, the report said. Studies also suggest that Viagra might help patients with congestive heart failure.

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China says it passes tougher food regulations, busts sellers of fake bird flu drugs, Viagra

July 26, 2007

China announced Wednesday that is strengthening its food safety regulations in the wake of discoveries of toxic chemicals that prompted a slew of international bans and recalls on its exports.

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New ‘Viva Viagra’ ads echo Elvis

July 25, 2007

Pfizer Inc. is singing a new tune when it comes to reviving sales of its impotence pill Viagra.

Pfizer will begin airing new TV ads today that feature a band of men in their 40s and 50s singing “Viva Viagra” to the tune of Elvis Presley’s “Viva Las Vegas.” The first ad, an attempt to make men less embarrassed about the disorder, will run during the NBC Nightly News, the company said.

Pfizer is struggling to boost sales of Viagra, which have fallen 11 percent to $1.7 billion since 2003, when Eli Lilly & Co.’s Cialis and Bayer AG’s Levitra became available. Pfizer, based in New York, says there’s still room for the market to grow because as few as 10 percent of the 33 million men in the U.S. with erectile dysfunction are treating the condition.

“This disease is very stigmatized and there are a lot of misperceptions,” said Ponni Subbiah, Pfizer’s medical director for Viagra. “Men are very willing to talk to their doctors about back pain or injuries, but not ED.”

Pfizer’s shares rose 37 cents, or 1.5 percent, to $25.27 at 12:15 a.m. in New York Stock Exchange composite trading. The shares have gained 4.5 percent in the past 12 months before today.

Sales of Viagra, which costs $10 a pill, rose 1 percent to $1.7 billion last year, while revenue from Eli Lilly’s rival Cialis gained 30 percent to $971 million, the companies reported. Pfizer spent $95 million on Viagra advertising last year, 61 percent more than Lilly, according to data from market research firm Nielsen Monitor-Plus.

Adult Time
The new ads will run during programming where 90 percent of viewers are adults. Pfizer declined to comment on how frequently the ads will run or how much it’s spending on the campaign.

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In a break from past Viagra advertising — which had spokesmen such as former senator and presidential candidate Bob Dole and television sex expert Dr. Drew Pinsky — this ad features middle-aged men playing guitars and driving motorcycles and vintage cars.

Advocacy groups and U.S. officials have criticized Pfizer in the past for its Viagra marketing tactics. The company had to pull a Viagra ad in 2004 that featured a man who grew devil horns when he walked past a lingerie store in a shopping mall. The U.S. Food and Drug Administration said the ads were misleading and didn’t properly warn of the risks.

The AIDS Healthcare Foundation, which runs 14 AIDS clinics in the U.S. and seven pharmacies, sued Pfizer in February claiming its Viagra marketing encourages recreational sex that can increase the risk of users getting the HIV virus. The lawsuit was dismissed, said Michael Weinstein, the president of the foundation.

Sin City
“Pfizer has been an outlier in shamelessly promoting Viagra as a party drug,” Weinstein said. “All those Sin City references, everything associated with Vegas, that is what they want the association to be. It’s not about a medical condition, it’s about performance anxiety.”

His group met with the FDA to express their concern about Viagra ads in the past, he said.

Pfizer is also studying new formulations and a possible non-prescription version of the drug that could increase usage, said Subbiah, who declined to comment on specific research projects. When Viagra came on the market in 1998 it quickly became one of Pfizer’s most successful products, helping the company become the world’s largest drugmaker.

Pfizer is racing to increase sales of its existing drugs with new television ads in an attempt to help replace some of the $21 billion in annual revenue it is at risk of losing by 2011 to generic competition.

Pfizer revived advertising for its painkiller Celebrex in April after a two-year hiatus following a recall of a similar drug, Merck & Co.’s Vioxx. This month it also began airing television ads for Exubera, an inhaled form of insulin that the company says has had disappointing sales since it came on the market last year.

Posted by toshko under Viagra News | Comments (0)

You’ve got mail - all you need is a way to get rid of it

July 21, 2007

You can’, my mother used to say, ‘have too much of a good thing’. Since she was generally not in favour of good things (which she equated with self-indulgence), I habitually disregarded this advice. But I am now beginning to wonder if she may have been right after all. This thought is sparked by an inspection of my email system. I have 852 messages in my ‘office’ inbox. Correction, make that 854: two more came in while I was typing that last sentence. My personal inbox has 1,304 messages. My spam-blocking service tells me that, in the past 30 days, I received no fewer than 3,920 invitations to: enhance my, er, physique; invest in dodgy shares; send money to the deserving widows of Nigerian dictators; and purchase Viagra. I am - literally - drowning in email.

And I am not alone. Everyone I know is feeling the same. In the New York Times the other day, Nora Ephron, the novelist and screenwriter (and the director of You’ve Got Mail), wrote a witty piece on ‘The Six Ages of Email’. They are: infatuation, clarification, confusion, disenchantment, accommodation and death. I particularly like her description of the ‘clarification’ phase. ‘It takes five seconds to accomplish in an email message something that takes five minutes on the telephone. The phone requires you to converse, to say things like hello and goodbye, to pretend to some semblance of interest in the person on the other end of the line. Worst of all, the phone occasionally forces you to make actual plans with the people you talk to - even if you have no desire whatsoever to see them. No danger of that with email.’

If I took it seriously, I could spend all day dealing with my email and never do any actual work. Which is why, increasingly, I tend to ignore my inboxes. This may seem discourteous, but in fact it isn’t - because much of ‘my’ email isn’t actually aimed primarily at me at all. I am just one of the people who is cc’d on the correspondence. In other words, people who are communicating with one another have added me as a kind of bystander. Their motives for doing this are varied. In some cases they are doing me a courtesy, or trying to persuade me that they’re not doing things behind my back. (Little do they know that I couldn’t care less.) In other cases, they are simply being lazy or covering their arses in case anything goes wrong, at which point they will say that I was ‘kept in the loop’ and accordingly must share some of the blame.

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The problem is not with email as such, but with the way organisations have subverted - or perverted - it for bureaucratic purposes. And they have done it for the same reason that spammers have perverted personal email: because it’s cheap and easy to do. In the old days, big organisations had massive internal mail systems, with post-rooms and messengers lugging bags or trolleys of paper. Email offered a way of dispensing with all this bother and expense. So organisations began to deluge employees with electronic documents. And the flood of email rapidly became the torrent that paralyses us today. Email has morphed from a communication channel into a means of bureaucratic control.

It can’t go on like this. Already some of the more alert businesses have realised that email has become a dysfunctional technology. They are instituting rules like a daily limit on the amount of time spent dealing with it. Or stipulating that email can only be done at the beginning and end of the working day. One organisation requires employees to don a red baseball cap when they are emailing, so that managers patrolling their open-plan offices can spot the addicts. I hear that one CEO of a US hi-tech firm has opened up his inbox so everyone can read it - with a corresponding reduction in sycophantic and attachment-laden messages.

Other solutions will doubtless emerge. In the meantime, here are some suggestions for refuseniks. First, change your own behaviour: always ask ‘is this email really necessary?’ before sending it. Never, ever send an email to a colleague in the next office. Set up a filter to block every message on which you are cc’d: deal only with messages addressed directly to you. Get yourself a private email address which is only known to your nearest and dearest.

And, finally, in extremis, call someone. As BT used to say, it’s good to talk.

Posted by toshko under Viagra News | Comments (0)

Viagra sales go limp after flourish

July 17, 2007

AHMEDABAD: The little blue pill, which has enabled many an Indian man to rise to the occasion, seems to be finding it difficult to get it up any further. The sales growth, that is! Viagra and its numerous desi cousins, a sure cure for erectile dysfunction (ED), have shown a minuscule growth of 5.43 per cent in sales.

As per latest ORG figures, the ED segment has clocked a turnover of Rs 121 crore for 12 months ending May 2007, as compared to a total turnover of Rs 115 crore seen during the same period last year. The sildenafil citrate-based drug was launched in the year 2001 and tadalafil was launched in 2003.

The market has grown from Rs 57 crore in 2003 to Rs 122 crore in 2007 — a compounded annual growth rate of 29 per cent. Soon after the launch of the drugs, growth in this segment ranged from 50 to 75 per cent, leading to all major pharma companies hankering after the ED dysfunction segment to produce Viagra clones for big business.

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Medicos attribute sluggish sales to growing apprehensions about sideeffects of the drugs. “The hype around sildenafil citrate has mellowed noticeably in the past two years. People had huge expectations from the drug, thinking it to be a ‘switch-on’ pill. Once they find it does not work like that, the segment, which was buying for fun has reduced, says psychiatrist and sex-therapist Dr Mrugesh Vaishnav.

Industry watchers attribute the slow sales growth of these pills to entry of sub-standard generic players, which have taken the lion’s share of the market. The top three brands now are Manforce (Mankind), Penegra (Zydus) and Caverta (Ranbaxy),which have a market share of 39 per cent, 14.21 per cent and 12.13 per cent respectively.

Medical experts insist that almost 50 per cent Viagra-clones are bought over the counter, rendering people vulnerable to side-effects. “Headache and visual disturbances have affected a lot of people who took the pill without proper guidance,” says psychiatrist Hansal Bhachech.

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